History:

Patient of Dr 

82 yo female presented with this rash on her face, neck and forearms in light-exposed areas 2 weeks after receiving an intravitreal injection for treatment of her macular degeneration. The rash began approx 5 days post-injection as a few "flat, brown spots" and then evolved into the rash seen below. Biopsy showed a prominent lichenoid inflammatory process with some necrotic keratinocytes in keeping with a drug reaction and, considering the clinical history, consistent with the diagnosis of drug-induced, subacute cutaneous lupus erythematosus.

This is the first documented evidence of an intravitreal injection of a monoclonal antibody causing a systemic reaction like SCLE.

We plan to publish this as a case report.

usually we see this as a reaction to lucentis for ARMD (age related mac degeneration) if the patient goes in the sun (Submitted By: Dr Leroy Rebello)