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Image Number #919 (Minocycline pigmentation)

Diagnosis: Minocycline pigmentation

Description: Ulceration with surrounding blue black pigmentation due to treatment

Morphology: Hyperpigmentation

Site: Leg

Sex: M

Age: 62

Type: Clinical

Submitted By: Ian McColl

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Differential Diagnosis
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History: Minocycline pigmentation can present in three ways namely as pigmentation of acne scars,or as diffuse pigmentation of the lower limbs or as a diffuse generalised hyperpigmentation.The latter two presentations seem to be dose related but not the former.In addition to the skin Minocycline can be deposited in cartilage,conjunctivae,bone,sclerae and teeth.After stopping the drug it can take years for the pigmentation to fade.The leg ulceration being treated with Minocycline was caused by Pyoderma gangrenosum.

DermNetNZ   eMedicine   PubMed   Dermatology Online   Archives   JAAD for "Minocycline pigmentation"

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