History:

A 67-year-old woman who is a known case of neurofibromatosis since early childhood presented with myriads of skin-colored soft nodules involving most of the face and many other parts of the body. The face mimicked a "bunch of grape" due to these tumors. The nodules were soft and can be pushed down into the panniculus by light pressure with the finger ("buttonholing") and spring back when released. Biopsy proved that these tumors are neurofibromas.